Product Details;
CasNo： 1191237-69-0
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1.What is the (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile ?
GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug.
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- 1355357-49-1
(2R,3R,4R,5R)‐2‐{4‐aminopyrrolo[2,1‐f][1,2,4]triazin‐7‐yl}‐3,4‐bis(benzyloxy)‐5‐[(benzyloxy)methyl]tetrahydrofuran‐2‐carbonitrile
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- 1191237-69-0
(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile
| Conditions | Yield |
|---|---|
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With boron trichloride; In dichloromethane; at 5 ℃;
|
95% |
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With 5%-palladium/activated carbon; hydrogen; In ethanol; at 45 - 50 ℃; under 750.075 - 900.09 Torr; Solvent; Reagent/catalyst;
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91.1% |
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(2R,3R,4R,5R)‐2‐{4‐aminopyrrolo[2,1‐f][1,2,4]triazin‐7‐yl}‐3,4‐bis(benzyloxy)‐5‐[(benzyloxy)methyl]tetrahydrofuran‐2‐carbonitrile; With boron trichloride; In dichloromethane; at -78 - -40 ℃; for 2h; Inert atmosphere;
With methanol; triethylamine; In dichloromethane;
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85% |
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With methanol; boron trichloride; triethylamine; In dichloromethane; for 0.0433333h; Temperature; Flow reactor;
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82% |
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With boron trichloride; In dichloromethane; at -78 ℃; Inert atmosphere;
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70% |
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With boron trichloride; In dichloromethane; at -20 - -15 ℃; for 1h;
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|
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Multi-step reaction with 2 steps
1.1: boron trichloride; Trimethyl borate / dichloromethane / 2 h / 0 - 35 °C
1.2: 12 h / 20 - 25 °C
2.1: potassium carbonate / water / 1 h / 20 °C
With Trimethyl borate; boron trichloride; potassium carbonate; In dichloromethane; water;
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- 1191237-68-9
(3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy) methyl)tetrahydrofuran-2-carbonitrile
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- 1191237-69-0
(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile
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- 1355049-95-4
(2S,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
| Conditions | Yield |
|---|---|
|
(3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy) methyl)tetrahydrofuran-2-carbonitrile; With boron trichloride; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;
With methanol; In dichloromethane;
|
37% 37% |
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With boron trichloride; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;
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37% 37% |
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With boron trichloride; In dichloromethane; at -78 - 0 ℃; for 3h;
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6% 22% |
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In dichloromethane; at -78 ℃; for 1h;
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|
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With boron trichloride; In dichloromethane; at -78 - -20 ℃; for 1h; Inert atmosphere;
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2.What is the CAS number for (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile ?
The CAS number of (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile is 1191237-69-0.
More information of (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile 1191237-69-0 are:
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CAS Number |
1191237-69-0 |
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Density |
1.84±0.1 g/cm3(Predicted) |
|
Melting Point |
> 233° C (dec.) |
3.What are another words for (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile ?
Synonyms for (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile 1191237-69-0:(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile
4.What is the molecular formula of (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile?
The chemical formula of (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile is C12H13N5O4 which containing 12 Carbon atoms,13 Hydrogen atoms,5 Nitrogen atoms and 4 Oxygen atoms,and the molecular weight of (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile is 291.266.
5.What is (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile (1191237-69-0) used for?
GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production (RNA synthesis arrest), either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection. Remdesivir is used as a treatment for Ebola virus disease and Marburg virus infections and other single stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus and the coronaviruses (including MERS and SARS viruses). Remdesivir is effective in the control of 2019-nCoV (COVID-19) infection in vitro. It now also has been studied as potential treatment of SARS-CoV-2 infections.
Relevant articles related to (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile:
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6.Buy (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile with the best price .
Shandong Hanjiang Chemical Co., Ltd. is a quality supplier of (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile 1191237-69-0.
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